4.5 Article

Iron(III) Chloride: A Versatile Catalyst for the Practical Synthesis of 3-Sulfenylindoles

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 9, Pages 1520-1524

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088035

Keywords

thiolation; indoles; thiols; 3-arylthioindoles

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The direct sulfenylation of indoles with aromatic thiols has been accomplished in the presence of 20 mol% of FeCl3 in refluxing acetonitrile to produce 3-arylthioindoles in relatively good to excellent yields and with high selectivity. This method works even with 2-unsubstituted indoles.

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