Journal
SYNTHESIS-STUTTGART
Volume -, Issue 19, Pages 3293-3300Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216916
Keywords
multicomponent reaction; N-heterocycles; catalysis; zirconium(IV) chloride; microwave
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Funding
- DST, New Delhi
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A microwave-promoted highly flexible and efficient Ugi-type multicomponent reaction of heterocyclic amidines With aldehydes and isocyanides catalyzed by zirconium(IV) chloride was developed. The general protocol offered the very reliable synthesis of a library of medicinally important, widely versatile N-fused aminoimidazoles in excellent yields. Poorly reactive heterocyclic amidines, functionally and sterically hindered aldehydes, which suffer as troublesome reactants in earlier described methods, were rendered as feasible substrates in this process. The efficient catalysis by ZrCl4 in addition to the effect of microwave irradiation was found crucial for gaining Superior flexibility and efficiency of the protocol.
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