Journal
SYNTHESIS-STUTTGART
Volume -, Issue 5, Pages 803-806Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218584
Keywords
beta-acetamido ketone; multicomponent reaction; cyanuric chloride; aqueous medium
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Funding
- CSIR
- UGC, New Delhi
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A one-pot, three-component reaction between an aromatic aldehyde, an enolizable ketone or a beta-keto ester, and a nitrile in the presence of acetyl chloride is accomplished efficiently using cyanuric chloride in an aqueous medium to give the corresponding beta-acetamido ketone or ester in high yield.
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