4.5 Article

Stereospecific Total Synthesis of (+)-Davana Acid, (+)-Nordavanone and (+)-Davanone

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 5, Pages 807-810

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218603

Keywords

Evans aldol; cyclic ether; (-)-linalool; natural product; davana oil

Funding

  1. CSIR, New Delhi

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A short, total synthesis of (+)-davana acid, (+)-nordavanone and (+)-davanone, which are principle components of davana oil, is described. The notable features are the use of the Evans syn aldol reaction and cyclic ether formation by an intramolecular S(N)2 displacement reaction as key steps.

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