Journal
SYNTHESIS-STUTTGART
Volume -, Issue 3, Pages 453-464Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1217116
Keywords
spiro compounds; indoles; catalysis; Bronsted acids; Bronsted bases; water
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Funding
- Ministry of Knowledge Economy (MKE) [RTI04-01-04]
- Korea Evaluation Institute of Industrial Technology (KEIT) [B0008557] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과C6B1910] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling.
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