Journal
SYNTHESIS-STUTTGART
Volume -, Issue 21, Pages 3530-3532Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1083182
Keywords
piperidines; PASE; one pot; multicomponent
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Funding
- EPSRC [EP/C523970/1]
- AstraZeneca
- Engineering and Physical Sciences Research Council [EP/C523970/2, EP/C523970/1] Funding Source: researchfish
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The diastereoselective pot, atom, and step economic (PASE) synthesis of highly functionalized piperidines is reported. The procedure simply involves mixing methyl acetoacetate, two equivalents of aldehyde and two equivalents of aniline together in the presence of indium(III) chloride. In most cases the piperidine precipitates out of solution.
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