4.5 Article

Synthesis of Tetrazolo[1,5-a]pyridines Utilizing Trimethylsilyl Azide and Tetrabutylammonium Fluoride Hydrate

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 24, Pages 4002-4006

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1083233

Keywords

tetrazolo[1,5-a]pyridines; 2-halopyridines; trimethylsilyl azide; tetrabutylammonium fluoride hydrate; palladium coupling

Funding

  1. Harvard Neuro-Discovery Center

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A method for the preparation of tetrazolo[1,5-a]pyridines from 2-halopyridines, utilizing trimethylsilyl azide in the presence of tetrabutylammonium fluoride hydrate, is described. In addition, 8-bromotetrazolo[1,5-a]pyridine is further transformed into a variety of novel tetrazolo[1,5-a]pyridine derivatives.

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