Journal
SYNTHESIS-STUTTGART
Volume -, Issue 20, Pages 3205-3208Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1083149
Keywords
Oxone (R); hydroxylation; iodobenzene; alpha-hydroxy ketones
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Funding
- State Key Laboratory of Applied Organic Chemistry
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Exposure of alkyl aryl ketones to Oxone (R)/trifluoroacetic anhydride in the presence of a catalytic amount of iodobenzene affords alpha-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the installation of alpha-hydroxy moieties into ketones and should find wide application in the construction of the a-hydroxy ketone subunit in natural product synthesis.
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