Synthesis, Characterization, and Cytotoxic Activity on MCF-7 Cell Line of Some Novel Metal Complexes With Substituted Benzimidazole Ligands

A series of novel metal complexes with the Schiff base ligands 4-((((1H-benzo[d]imidazol-2-yl)methyl)imino)methyl) benzene-1,3-diol, H3L1, and (((1H-benzo[d]imidazol-2-yl)methyl) thio)propanenitrile, HL2, have been synthesized and identified by elemental and spectral (UV-vis, IR, 1H NMR, mass) analyses, molar conductivities, as well as magnetic moment measurements technique. The ligands behave either as neutral tridentate or bidentate ligand. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7. Ag and Cu complexes 2, 8 and 9 showed a remarkable smaller value of IC50 than that of the Tamoxifen, the standard. This would provide a new potential antitumor drug that deserves more attention.