Journal
GENOME MEDICINE
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13073-015-0173-z
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Complete loss of gene function in humans by naturally occurring biallelic loss-of-function mutations (human knockout) is not a new concept. However, the recent identification of human knockouts along the entire spectrum of health and disease by next-generation sequencing promises to unlock their full potential to accelerate the medical and functional annotation of the human genome.
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