Journal
SYNLETT
Volume 29, Issue 18, Pages 2342-2361Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1609584
Keywords
[2+2+2] cyclotrimerization; Diels-Alder; sultine; amino acids and peptides; spirocycles; Wilkinson's catalyst; Vollhardt's catalyst; alkyne surrogates
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Funding
- Department of Science and Technology (DST), New Delhi [EMR/2015/002053]
- CSIR-New Delhi
- DST [SR/S2/JCB-33/2010]
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The [2+2+2] cycloaddition reaction is a useful tool to realize unusual chemical transformations which are not achievable by traditional methods. Here, we report our work during the past two decades that involve utilization of transition-metal complexes in a [2+2+2] cyclotrimerization reaction. Several key building blocks were assembled by a [2+2+2] cycloaddition approach and they have been further expanded by other synthetic transformations to design unusual amino acids and peptides, diphenylalkanes, bis-and trisaryl benzene derivatives, annulated benzocycloalkanes, spirocycles, and spirooxindole derivatives. Furthermore, we have also discussed about alkyne surrogates, environmentally friendly, and stereoselective [2+2+2] cycloaddition reactions. Application of the [2+2+2] cycloaddition reaction in total synthesis is also covered. In this review we also included others work to give a balanced view of the recent developments in the area of [2+2+2] cycloaddition.
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