Journal
SYNLETT
Volume 29, Issue 16, Pages 2171-2175Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1610551
Keywords
atropisomerism; amino alcohols; enantioselectivity; asymmetric catalysis; phenylpyrrole; ligands
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Funding
- National Research, Development and Innovation Office of Hungary (NKFIH) [PD129652, K104528]
- Richter Gedeon Talentum Foundation
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Syntheses of two regioisomeric series of atropisomeric amino alcohols and a comparative study on their application in the enantioselective addition of diethylzinc to benzaldehyde are reported. Systematic modification of the electronic and steric properties of the functional groups resulted in highly efficient catalyst ligands in both series. Quantum-chemical calculations agreed well with the experimental results of this first systematic comparative study on regioisomeric atropisomeric ligands.
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