Journal
SYNLETT
Volume 26, Issue 3, Pages 335-339Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1379015
Keywords
copper; oxidation; indoles; oxygen; TEMPO
Categories
Funding
- National Institutes of Health [RO1 GM078383]
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A copper-catalyzed intramolecular alkene oxidative amination that utilizes TEMPO as cocatalyst and O-2 as the terminal oxidant has been developed. The method furnishes N-aryl and N-sulfonyl indoles from N-aryl and N-sulfonyl 2-vinylanilines, respectively. Additionally, sequential copper-catalyzed reactions where initial Chan-Lam coupling of 2-vinylanilines with arylboronic acids is followed by oxidative amination of the alkene can generate N-aryl indoles in one pot.
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