Journal
SYNLETT
Volume 25, Issue 12, Pages 1717-1720Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1339156
Keywords
indanones; polyphosphoric acid; electrophilic aromatic substitution; total synthesis; regioselectivity
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Funding
- European Research Council (Advanced Investigator Grant) [227897]
- Netherlands Organization for Scientific Research (NWO-CW)
- Ministry of Education, Culture and Science (Gravity program) [024.001.035]
- NRSC-catalysis
- DAAD
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The degree of hydrolysis of polyphosphoric acid (PPA) has a crucial effect on the regioselectivity of the PPA-mediated synthesis of indanones. It was found that the regioselectivity can be switched by employing PPA with either a high or low content of P2O5. This methodology was used for the regioselective synthesis of a range of electron-rich indanones, including a natural sesquiterpene.
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