4.4 Article

Bu4NI-Catalyzed Synthesis of Imidazo[1,2-a]pyridines via Oxidative Coupling of Aminopyridines with Nitroolefins

Journal

SYNLETT
Volume 25, Issue 5, Pages 718-720

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1340485

Keywords

TBAI; imidazo[1; 2-a]pyridines; oxidative coupling; aminopyridines; nitroolefins

Funding

  1. National Natural Science Foundation of China [21102130]
  2. Key Innovation Team of Science & Technology in Zhejiang Province [2010R50018, 2011R50017]

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A metal-free method for the synthesis of imidazo[1,2-a]pyridines via double C-N oxidative coupling of aminopyridines with nitroolefins using TBAI as the catalyst and TBHP as oxidation agent has been developed.

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