Journal
SYNLETT
Volume 25, Issue 10, Pages 1478-1481Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1339012
Keywords
metal-free; 4H-pyrido[1,2-a]pyrimidin-4-ones; PTSA; 2-aminopyridine; multicomponent reactions
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Funding
- Foundation for Natural Science Foundation of Guangdong Province [S2013040012962]
- Distinguished Young Talents in Higher Education of Guangdong [2012LYM_0086]
- National Natural Science Foundation of China [21302023]
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A novel one-pot protocol has been developed for the construction of alkenylated 4H-pyrido[1,2-a]pyrimidin-4-one derivatives from 2-aminopyridine in the presence of PTSA. The present approach opens a new way for the formation of C-C and C-N bonds under mild conditions.
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