4.4 Article

Copper-Catalyzed Oxidative Electrophilic Carbofunctionalization of Acrylamides for the Synthesis of Oxindoles

Journal

SYNLETT
Volume 25, Issue 14, Pages 2009-2012

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1378354

Keywords

copper-catalyzed; acrylamides; diphenyliodonium triflate; oxindoles; electrophilic arylation

Funding

  1. Chinese National Natural Science Foundation [21173178, 21232005, 21375113]
  2. National Basic Research Program of China [2012CB821600]
  3. Program for Changjiang Scholars and Innovative Research Team in University

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A novel and efficient copper-catalyzed tandem oxidative cyclization of arylacrylamides with diaryliodonium salts is reported. This reaction provides a novel approach for the synthesis of oxindoles and various functional groups were well tolerated.

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