Journal
SYNLETT
Volume 24, Issue 6, Pages 666-685Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1318222
Keywords
biocatalysis; chemoselectivity; molecular complexity; molecular diversity; multicomponent reaction
Categories
Funding
- Netherlands Organization for Scientific Research
Ask authors/readers for more resources
Multicomponent reactions (MCRs) are versatile syntheses for obtaining structurally diverse sets of complex scaffolds with high efficiency. As such, they can be attractive synthetic tools for the realization of diversity- and/or biology-oriented synthesis design strategies for focused libraries. In this account, we present an overview of our contribution to the design of novel MCRs to access a high level of molecular complexity and diversity. In addition, we demonstrate our biocatalysis/MCR sequences to obtain stereoenriched product scaffolds. 1 Introduction 2 The Build/Couple/Pair Strategy 3 Rational Design of Multicomponent Reactions 3.1 Single Reactant Replacement 3.2 Modular Reaction Sequences 3.3 Conditions-Based Divergence 3.4 The Combination of Multicomponent Reactions 4 Palladium-Catalyzed Isocyanide Reactions 5 The Quest for Stereoselective Multicomponent Reactions 6 Conclusion
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available