Journal
SYNLETT
Volume 24, Issue 18, Pages 2411-2418Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1339870
Keywords
heterocycles; cross coupling; flow chemistry; C-H activation; catalysis
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Funding
- Austrian Science Fund (FWF) [P21202-N17, S107]
- Vienna University of Technology Doctorate Program 'Catalysis Materials and Technology - CatMat'
- Austrian Science Fund (FWF) [S107] Funding Source: Austrian Science Fund (FWF)
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Suzuki-Miyaura cross-coupling reactions between heteroaryl bromides and arylboronic acids were performed employing a continuous-flow approach using a simple flow reactor designed in-house. Pd(PPh3)(4) was used as catalyst, and arylboronic acids containing both electron-withdrawing and electron-donating groups were applied. The coupling process required 23 minutes of residence time to be completed and generally good yields were obtained. Subsequent arylation of 2-phenyl pyridine was carried out via a C-H activation strategy using substituted bromobenzene compounds and a ruthenium(II) catalyst. To the best of our knowledge in this work we present for the first time the possibility of performing intermolecular C-H activation in a continuous-flow system.
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