4.4 Article

An Efficient Oxidative Cross-Coupling Reaction between C-H and N-H Bonds; A Transition-Metal-Free Protocol at Room Temperature

Journal

SYNLETT
Volume 24, Issue 15, Pages 2009-2013

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1339447

Keywords

metal-free; cross-coupling; oxidative coupling; amination; C-H activation

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A transition-metal-free oxidative coupling of allylic C-H and heterocyclic/aromatic N-H bonds was performed under mild conditions. Promoted by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), up to 99% yield could be achieved.

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