Efficient H-D Exchange Reactions Using Heterogeneous Platinum-Group Metal on Carbon-H2-D2O System

Deuterium-labeled compounds are widely utilized in various scientific fields. Although the H-D exchange reaction is a straightforward method to produce the deuterated organic compounds, it requires expensive deuterium (D-2) gas and/or harsh reaction conditions in conventional methods. This Account summarizes platinum-group metal on carbon (e. g., Pd/C, Pt/C, Ru/C, Rh/C)-catalyzed efficient multi and/or site-selective H-D exchange methods of various compounds including bioactive molecules, such as amino acids, nucleic acids, pharmaceuticals, agrochemicals, and sugars, under neutral and H-2-atmospheric conditions in D2O.