Journal
SYNLETT
Volume -, Issue 7, Pages 959-972Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1289696
Keywords
H-D exchange; D-2 gas; heterogeneous catalysis; platinum-group metals; isotope labeling
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Deuterium-labeled compounds are widely utilized in various scientific fields. Although the H-D exchange reaction is a straightforward method to produce the deuterated organic compounds, it requires expensive deuterium (D-2) gas and/or harsh reaction conditions in conventional methods. This Account summarizes platinum-group metal on carbon (e. g., Pd/C, Pt/C, Ru/C, Rh/C)-catalyzed efficient multi and/or site-selective H-D exchange methods of various compounds including bioactive molecules, such as amino acids, nucleic acids, pharmaceuticals, agrochemicals, and sugars, under neutral and H-2-atmospheric conditions in D2O.
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