Journal
SYNLETT
Volume -, Issue 18, Pages 2714-2718Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1317350
Keywords
palladium; arylation; arylsulfonyl chlorides; phosphine; benzoxazoles
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Funding
- Research Grants Council of Hong Kong [GRF: PolyU5014/10P]
- PolyU Development Grant [1BD07]
- State Key Laboratory of Chirosciences [BBX-3]
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This study describes a direct oxidative C-2 arylation of benzoxazoles using arylsulfonyl hydrazides as the aryl sources. A simple catalyst system [Pd(OAc)(2) and Ph3P] allows the reactions to proceed smoothly under oxidative reaction conditions. Other heteroarenes such as caffeine and benzothiazole are also applicable substrates. Notably, this catalytic system tolerates halogen substituents which provides a useful complement to the current cross-coupling reactions which use aryl halides.
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