Journal
SYNLETT
Volume -, Issue 15, Pages 2179-2182Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290445
Keywords
alkynes; alkyl halides; azides; cycloaddition; copper; cross-coupling; heterocycles; multicomponent reaction
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Funding
- Spanish Ministerio de Ciencia e Innovacion (MICINN) [CTQ2007-65218, Consolider Ingenio 2010-CSD2007-00006]
- Generalitat Valenciana (GV) [PROMETEO/2009/039]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Instituto de Sintesis Organica (ISO) of the Universidad de Alicante
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Copper(I) oxide has been found to effectively catalyse the multicomponent click synthesis of fully substituted 5-alkynyl 1,2,3-triazoles from organic halides, sodium azide, and terminal alkynes in methanol under ambient conditions.
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