4.4 Article

Synthesis of Monofluoroalkenes via the Activation of Allylic C-F Bonds: A Novel Route to β-Aminofluoroalkenes Using Pd-Catalyzed Allylic Amination Reactions of 3,3-Difluoropropenes

Journal

SYNLETT
Volume -, Issue 3, Pages 289-293

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1259333

Keywords

C-F activation; organofluorine chemistry; fluoroalkenes; palladium; homogeneous catalysis

Funding

  1. Canada Research Chair Program
  2. Natural Sciences and Engineering Research Council of Canada
  3. Canada Foundation for Innovation
  4. Fonds de recherche sur la nature et les technologies
  5. Pfizer Global Research Development
  6. Universite Laval

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This article portrays the development of a novel and efficient synthetic route to beta-aminofluoroalkenes, from readily available 3,3-difluoropropenes and amines, that proceeds via the activation of an allylic C-F bond.

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