Journal
SYNLETT
Volume -, Issue 15, Pages 2181-2184Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1261197
Keywords
heterocycles; natural products; cyclisation; antibiotics; lactams
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Funding
- EPSRC [GR/T20380/01]
- Korea Research Foundation
- Korean Government (MOEHRD) [KRF-2006-352-C00044]
- British Commonwealth Scholarship Commission UK [INCF-2008-68]
- EC [FP7/REGPOT-2009-1/BioSupport]
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The synthesis of a lactam-lactone bicyclic system containing a pyroglutamate subunit proceeds to give the fused lactone system, which is favoured over the spirocyclic lactone alternative. These systems display no or weak antibacterial activity against the test organisms S. aureus and E. coli.
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