Ammonium Phosphorodithioate: A Mild, Easily Handled, Efficient, and Air-Stable Reagent for the Conversion of Amides into Thioamides

A simple, efficient, and new method has been developed for the synthesis of thioamides from amides. As described below, the reaction of a variety of aromatic and aliphatic amides in the presence of ammonium phosphorodithioate as an efficient reagent proceeded effectively to afford the corresponding thioamides in high yields. This method is easy, rapid, and high-yielding for the synthesis of thioamides from amides using an easily handled reagent.