Journal
SYNLETT
Volume -, Issue 8, Pages 1073-1080Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260540
Keywords
alkenoyl ketene dithioacetals; 1,5-bielectrophiles; dialkylthio group; [5+1] annulation; carbo- and heterocyclic systems
Categories
Funding
- Fundamental Research Funds for the Central Universities [NENU-STC08007/07007]
- Science Foundation for Young Teachers of Northeast Normal University [09 QNJJ017]
- [NNSFC-21072027]
Ask authors/readers for more resources
Functionalized ketene dithioacetals are versatile intermediates in organic synthesis. The important multiple roles of the dialkylthio group make these substrates particularly useful for the synthesis of a number of important classes of substituted carbo-and heterocyclic systems, such as thiophenes, lactones, pyrroles, furans, pyridines, substituted cyclohexanones, and benzene derivatives. This account focuses on the utility of alkenoyl ketene dithioacetals, which have been found useful in the synthesis of six-membered carbo- and heterocyclic systems relying upon utilization of alkenoyl ketene dithioacetals, as the 1,5-bielectrophilic component in the [5+1] annulation with carbon, nitrogen, sulfur, and other nucleophiles. 1 Introduction 2 Synthesis of Alkenoyl Ketene Dithioacetals 2.1 Synthesis of a-Acetyl Ketene Dithioacetals 2.2 Synthesis of Alkenoyl Ketene Dithioacetals 3 [5C+1C] Annulation 3.1 Synthesis of Substituted Phenols, Cyclohexenones, and Hindered Benzophenones 3.2 Synthesis of Unsymmetrical Biaryls and p-Terphenyls 4 [5C+1N] Annulation 4.1 Synthesis of Functionalized 2,3-Dihydro-4-pyridones and Bipyridines 4.2 Synthesis of Substituted Pyridines 5 [5C+1S/Se] Annulation 6 Future Directions 7 Conclusions
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available