4.4 Article

Hydrazone-Promoted Sonogashira Coupling Reaction with Aryl Bromides at Low Palladium Loadings

Journal

SYNLETT
Volume -, Issue 9, Pages 1277-1280

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260535

Keywords

palladium; catalysis; Sonogashira coupling reaction; hydrazone

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The Sonogashira coupling reaction of aryl bromides with a variety of terminal alkynes in DMSO at 125 degrees C gave internal arylated alkynes using low-loaded Pd(acac)(2) with hydrazone as a ligand and CuI as the co-catalyst in good yields.

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