Journal
SYNLETT
Volume -, Issue 6, Pages 852-865Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1219528
Keywords
binol phosphate; Bronsted acid; Hantzsch ester; transfer hydrogenation; organocatalysis; asymmetric reduction
Categories
Funding
- Evonik Degussa
- DFG
- FCI (Fonds der Chemischen Industrie)
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Asymmetric hydrogenations are of great importance in the synthesis of optically active amines. This account highlights the development of the first metal-free transfer hydrogenation that is both highly enantioselective and inspired by nature's dehydrogenase. Further focus is given to the extension of this bioinspired process to provide a variety of valuable, biologically active products and natural products under mild reaction conditions.
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