4.4 Article

Ligand-Free Copper-Catalyzed Synthesis of Diaryl Thioethers from Aryl Halides and Thioacetamide

Journal

SYNLETT
Volume -, Issue 1, Pages 134-138

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1259079

Keywords

copper; catalysis; cross-coupling; diaryl thioether; arylation; thioacetamide

Funding

  1. Natural Science Foundation of Jiangsu Education Committee [10KJB150001]
  2. Jiangsu Key Laboratory of Marine Biotechnology [2009HS02]
  3. Jiangsu Marine Resources R D Institute [JSIMR10C05]
  4. Huaihai Institute of Technology [KQ09030]

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Diaryl thioethers can be prepared via a copper-catalyzed cross-coupling between aryl halides and thioacetamide using Cs2CO3 as a base and DMSO-H2O as a solvent at 120 degrees C.

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