4.4 Article

Ag2O-Mediated Intramolecular Oxidative Coupling of Acetoacetanilides for the Synthesis of 3-Acetyloxindoles

Journal

SYNLETT
Volume -, Issue 17, Pages 2607-2610

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258584

Keywords

3-acetyloxindoles; acetoacetanilides; Ag2O; oxidative coupling

Funding

  1. National Natural Science Foundation of China [20772053]

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The intramolecular oxidative Csp(2)-Csp(3) coupling of N-substituted acetoacetanilides was achieved by using Ag2O as the oxidant. The reaction constitutes a convenient approach toward 3-acetyloxindoles from unfunctionalized acetoacetanilides.

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