Journal
SYNLETT
Volume -, Issue 12, Pages 1849-1853Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258126
Keywords
green chemistry; homogeneous catalysis; asymmetric catalysis; enones; Michael reaction
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A high-yielding reaction protocol for the microwave-assisted organocatalytic conjugate addition of diethyl malonate to enones under solvent-free conditions is proposed. The method still permits the use of cheap and commercially available L-proline furnishing very good performance at least in the case of 1-alkyl-3-monosubstituted enones.
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