4.4 Article

Microwave-Promoted Alkynylation-Cyclization of 2-Aminoaryl Ketones: A Green Strategy for the Synthesis of 2,4-Disubstituted Quinolines

Journal

SYNLETT
Volume -, Issue 20, Pages 3104-3112

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1259065

Keywords

2,4-disubstituted quinolines; K5CoW12O40 center dot 3H(2)O; microwave irradiation; 2-aminoaryl ketones; arylacetylenes

Funding

  1. Center of Excellence of Chemistry
  2. Research Council of the University of Isfahan

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A series of 2,4-disubstituted quinolines were easily prepared through a one-pot reaction of structurally diverse 2-aminoaryl ketones with various arylacetylenes in the presence of K5CoW12O40 center dot 3H(2)O as a reusable and environmentally benign catalyst under microwave irradiation and solvent-free conditions.

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