4.4 Article

A Novel Indium-Catalyzed Three-Component Reaction: General and Efficient One-Pot Synthesis of Substituted Pyrroles

Journal

SYNLETT
Volume -, Issue 15, Pages 2345-2351

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258525

Keywords

pyrrole; indium; one-pot reaction; propargylic acetate; enoxysilane

Funding

  1. National Natural Science Foundation of China [20772098]

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A convenient and general approach towards the synthesis of substituted pyrroles from propargylic acetates, silyl enol ethers, and primary amines was described. This novel transformation was catalyzed by indium trichloride in a one-pot synthesis, and high yields of various pyrrole derivatives were obtained.

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