Journal
SYNLETT
Volume -, Issue 5, Pages 749-752Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1219344
Keywords
microreactor; flow chemistry; pyrrolidine; dipolar cycloaddition; solid-supported reagents
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Funding
- Cambridge European Trust
- Ralph Raphael Studentship award
- Royal Society
- BP endowment
- EPSRC [EP/G028125/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G028125/1] Funding Source: researchfish
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The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using the H-Cube (R) system. To ensure product purities in excess of 90-95%, immobilised scavengers were successfully employed.
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