4.4 Article

Three-Component Fischer Indole Synthesis

Journal

SYNLETT
Volume -, Issue 15, Pages 2296-2298

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258037

Keywords

indoles; Fischer; Japp-Klingeman; diazonium; hydrazone; acid chloride; multicomponent reaction

Funding

  1. Ecole Polytechnique
  2. ENSTA

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Three-component coupling between acyl chlorides, diazonium salts, and alcohols or amines allows the formation of alpha-hydrazono carboxylic acid derivatives which may be directly converted into indoles by a Fischer-type cylization.

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