4.4 Article

New Methodologies for the Synthesis of 3-Acylpyridone Metabolites

Journal

SYNLETT
Volume -, Issue 4, Pages 654-658

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1219341

Keywords

heterocycles; cycloaddition; metalation; aldol reaction; pyridone

Funding

  1. Open University
  2. Loughborough University
  3. Syngenta

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A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products.

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