4.4 Article

Organocatalytic Enantioselective Aza-Friedel-Crafts Alkylation of Pyrroles with N-(Heteroarenesulfonyl)imines

Journal

SYNLETT
Volume -, Issue 10, Pages 1639-1642

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1217324

Keywords

amines; Asymmetric synthesis; aza-Friedel-Crafts alkylation; heteroarylsulfonyl group; organocatalysis

Funding

  1. JSPS [20750074]
  2. Grants-in-Aid for Scientific Research [20750074] Funding Source: KAKEN

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Organocatalytic enantioselective aza-Friedel-Crafts alkylation of pyrroles with imines having heteroarylsulfonyl groups catalyzed by binaphthol monophosphoric acids afforded products with high enantioselectivity (up to 95% ee).

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