Journal
SYNLETT
Volume -, Issue 16, Pages 2643-2646Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1217749
Keywords
heterocycles; condensation; fused-ring systems; tandem reactions; Michael additions
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Funding
- National Institutes of Health [GM-081253]
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An efficient protocol to annulate the 5,6-fused 2-pyridone ring system, exploiting a tandem condensation of propiol-amide and cyclic beta-keto methyl esters in water, followed by acid- or base-promoted intramolecular ring closure and decarboxylation, has been developed.
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