4.4 Article

A Procedure for Fast and Regioselective Copper-Free Click Chemistry at Room Temperature with p-Toluenesulfonyl Alkyne

Journal

SYNLETT
Volume -, Issue 9, Pages 1409-1412

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216744

Keywords

cycloadditions; regioselectivity; copper-free click chemistry; solvent-free reaction; p-toluenesulfonyl alkyne

Funding

  1. Centre National de la Recherche Scientifique
  2. Ministere Delegue l'Enseignement Superieur et la Recherche
  3. Conseil Regional de Picardie

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Sulfonyl alkyne group can undergo copper-free cyclization at room temperature with diverse azido compounds. In solvent-free conditions the reaction was fast, yielding 1,4-disubstituted regioisomers with high regioselectivity.

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