4.4 Article

A Novel Consecutive Three-Component Coupling-Addition-SNAr (CASNAR) Synthesis of 4H-Thiochromen-4-ones

Journal

SYNLETT
Volume -, Issue 8, Pages 1255-1260

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216735

Keywords

alkynes; catalysis; CC coupling; heterocycles; multi-component reactions

Funding

  1. Fonds der Chemischen Industrie

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4H-Thiochromen-4-ones and 4H-thiopyrano[2,3-b]pyridin-4-ones are readily synthesized in good yields by a consecutive one-pot, three-component coupling-addition-SNAr (CASNAR) sequence starting from aroyl chlorides, alkynes, and sodium sulfide nonahydrate.

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