Journal
SYNLETT
Volume -, Issue 1, Pages 101-106Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218530
Keywords
copper; Ullmann-type reaction; cross-coupling; quinazoline; synthetic method
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Funding
- National Natural Science Foundation of China [20672065, 20732004, 20872010, 20972083]
- Chinese 863 Project [2007AA02ZI60, 2006DFA43030]
- Key Subject Foundation from Beijing Department of Education [XK100030514]
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We have developed an efficient copper-catalyzed method for the synthesis of 4-aminoquinazoline and 2,4-diaminoquinazoline derivatives via reactions of substituted 2-bromobenzonitriles with amidines or guanidine, and the method is of economical and practical advantage.
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