Journal
SYNLETT
Volume -, Issue 20, Pages 3263-3266Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218381
Keywords
1,2,4-trisubstituted 1H-imidazoles; aldehydes; primary amines; four-component reactions; cyclizations; heterocycles
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Funding
- Research Council of University of Tehran [6102036/1/03]
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A one-pot, four-component synthesis of 1,2,4-trisubstituted 1H-imidazoles is described. Heating a mixture of a 2-bromoacetophenone, an aldehyde, a primary amine, and ammonium acetate under solvent-free conditions affords functionalized imidazoles in good to excellent yields.
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