Journal
SYNLETT
Volume -, Issue 20, Pages 3378-3382Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218388
Keywords
propylphosphonic anhydride; dehydration; nitriles; aldoximes; electrophilic activation
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Funding
- Syngene International Ltd.
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Propylphosphonic anhydride has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P (R) as a versatile reagent in organic chemistry.
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