4.4 Article

A New Approach to 3-Substituted Indoles through Palladium-Catalyzed C-H Activation Followed by Intramolecular Amination Reaction of Enamines

Journal

SYNLETT
Volume -, Issue 20, Pages 3157-3162

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1087413

Keywords

palladium; catalysis; C-H activation; indoles; aminations

Funding

  1. Japan Society for the Promotion of Science (JSPS)

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Palladium-catalyzed C-H activation followed by intramolecular amination reaction of enamine compounds was achieved using a Pd(OAc)(2) (10 mol%)/Cu(OAc)(2) (100 mol%) catalyst system in DMSO. This work introduces an entirely new approach to 3-substituted indoles.

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