Journal
SYNLETT
Volume -, Issue 14, Pages 2161-2163Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1078018
Keywords
multicomponent reactions; Passerini reaction; phosphates; phosphorylation; prebiotic chemistry
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Funding
- Engineering and Physical Sciences Research Council
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Monoalkyl phosphates can take the place of carboxylic acids in the Passerini reaction, but excesses of aldehyde an isonitriles are required, and transfer of the phosphate to the newly formed hydroxyl group does not take place. By rendering the phosphate addition intramolecular, the efficiency of the reaction is substantially increased. Phosphate transfer can take place when cyanovinyl phosphate is used rather than a monoalkyl phosphate.
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