Journal
SYNLETT
Volume -, Issue 5, Pages 645-648Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1032106
Keywords
combinatorial chemistry; dehydrogenations; multicomponent reactions; isocyanides; quinoxalines
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A novel multicomponent reaction of o-phenylenediamines with aldehydes and isonitriles yields 1,4-dihydroquinoxalines. These intermediates are unstable under reaction conditions. They undergo oxidation with DDQ to furnish 33-54% isolated yields of the respective quinoxalines. This reaction is general for aromatic 1,2-diamines. Monoalkylated aryl 1,2-diamines lead to stable 1,4-dihydroquinoxalines.
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