Journal
SYNLETT
Volume -, Issue 1, Pages 43-46Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1087387
Keywords
lamellarins; Friedel-Crafts acylation; esterification; bromoarylation; oxidative cyclization
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Funding
- CSIR, New Delhi
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A modular synthesis of the lamellarin G trimethyl ether has been developed based on the application of several reaction sequences which include Friedel-Crafts acylation, esterification, haloarylation, and oxidative cyclization. The formation of pyrrolo [2,1-a]isoquinoline core, the key step for the successful completion of lamellarin G trimethyl ether synthesis, is comfortably accomplished through the haloarylation of 3-bromo-4-(3,4-dimethoxy-benzoyl)-6,7-dimethoxy-chroman-2-one which has resulted in exclusive endo product.
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