Journal
SYNAPSE
Volume 65, Issue 7, Pages 624-633Publisher
WILEY-BLACKWELL
DOI: 10.1002/syn.20883
Keywords
normal database; serotonin; serotonin transporter; serotonin 1A receptor; positron emission tomography
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Funding
- Ministry of Education, Culture, Sports and Technology (MEXT), Japanese Government
- Japan Society for the Promotion of Science [20591382]
- Grants-in-Aid for Scientific Research [21591587, 20591382] Funding Source: KAKEN
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The central serotonergic (5-HT) system is closely involved in regulating various mental functions such as mood and emotion. In this system, the serotonin transporter (5-HTT) and the 5-HT1A receptor play important roles in the pathophysiology and treatment of mood and anxiety disorders. However, only a few integrated databases have considered the intraindividual relationship between pre-and postsynaptic serotonergic transmission. In the present study, we constructed a database of 5-HTT and 5-HT1A receptors using positron emission tomography (PET) with [C-11]DASB and [C-11]WAY100635, respectively. Seventeen healthy young men participated in this study. After anatomic standardization of original images, BPND was calculated on a voxel-byvoxel basis using reference tissue methods. The highest binding to 5-HTT was observed in the dorsal raphe nucleus, striatum, and thalamus; moderate binding, in the insula and cingulate cortex; and very low binding, in the cerebral neocortex. In contrast, the highest binding to 5-HT1A receptors was seen in the hippocampal regions, insula, neocortical regions, and dorsal raphe nucleus, and very low binding was found in the thalamus and basal ganglia. These distribution patterns were in agreement with those reported in human postmortem studies and previous PET investigations. In addition, exploratory analysis indicated significant negative correlations between the BPND values with both radiotracers in certain regions of the brain, such as the cingulate, insula, and frontal, temporal and parietal cortices (Pearson's correlation, P < 0.05). These databases facilitate the understanding of the regional distribution of serotonergic neurotransmission function in the living human brain and the pathophysiology of various neuropsychiatric disorders. Synapse 65: 624-633, 2011. (C) 2010 Wiley-Liss, Inc.
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