Journal
SYNAPSE
Volume 64, Issue 1, Pages 92-96Publisher
WILEY
DOI: 10.1002/syn.20714
Keywords
cannabinoid; anorexia nervosa; bulimia nervosa; atypical eating disorders
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Funding
- William Paterson University Center for research
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Marijuana use activates cannabinoid receptors (CB-Rs) producing several behavioral effects related to addiction, mood, and appetite. We investigated the association between CNR2 gene, which encodes cannabinoid CB2 receptor (CB2-R) and eating disorders in 204 subjects with eating disorders and 1876 healthy volunteers in Japanese population. The effect of treatment with CB2-R ligands on mouse food consumption was also determined. The CB2-R ligands used suppressed food intake in a time- and strain-dependent manner when food was available ad libitum and during the 12-h fast except, AM 630-the CB2-R antagonist that stimulated food consumption in food-deprived mice. There is an association between the R63Q polymorphism of the CNR2 gene and eating disorders (P = 0.04; Odds ratio 1.24, 95% CI, (1.01-1.53). These results suggest that cannabinoid CB2-R is involved in the endocannabinoid signaling mechanisms associated with the regulation of food intake and in eating disorders. Synapse 64:92-96, 2010. (C) 2009 Wiley-Liss, Inc.
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